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PELI1 Mouse anti-Human, Clone: OTI10D1, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF807741

Catalog No. 50-166-8454


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.
Specifications

Specifications

PELI1
Monoclonal
Unconjugated
PELI1
Lyophilized
PELI1
Human recombit protein fragment corresponding to amino acids 1-245 of human PELI1 produced in E.coli.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Western Blot
OTI10D1
PBS with 8% trehalose and no preservative; pH 7.3
Q96FA3
pellino E3 ubiquitin protein ligase 1
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
57162
SDS
Documents
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