PELI1 Mouse anti-Human, Clone: OTI10D1, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF807741

Catalog No. 50-166-8454

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.

Specifications

• Antigen: PELI1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: PELI1
• Gene Alias: pellino E3 ubiquitin protein ligase 1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57162
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI10D1
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q96FA3
• Gene Symbols: PELI1
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-245 of human PELI1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1