Invitrogen™ Pellino 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532090

Catalog No. PIPA532090

Description

Recommended positive controls: THP-1, HL-60. Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (81%), Chicken (99%), Rhesus Monkey (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.

Specifications

• Antigen: Pellino 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PELI1
• Gene Alias: 2810468L03Rik; A930031K15Rik; AA409794; AI586297; D11Ertd676e; E3 ubiquitin-protein ligase pellino homolog 1; Peli1; pellino 1; pellino E3 ubiquitin protein ligase 1; pellino homolog 1; pellino1; pellino-1; Pellino-related intracellular-signaling molecule; PRISM; protein pellino homolog 1; RING-type E3 ubiquitin transferase pellino homolog 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57162
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.71 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q96FA3
• Gene Symbols: PELI1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Pellino1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov