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Invitrogen™ Pellino 1 Polyclonal Antibody
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Catalog No. PIPA532090
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100 μL
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PIPA532090 100 μL
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Catalog No. PIPA532090 Supplier Invitrogen™ Supplier No. PA532090
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: THP-1, HL-60. Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (81%), Chicken (99%), Rhesus Monkey (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Pellino 1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.71 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene PELI1
Gene Accession No. Q96FA3
Gene Alias 2810468L03Rik; A930031K15Rik; AA409794; AI586297; D11Ertd676e; E3 ubiquitin-protein ligase pellino homolog 1; Peli1; pellino 1; pellino E3 ubiquitin protein ligase 1; pellino homolog 1; pellino1; pellino-1; Pellino-related intracellular-signaling molecule; PRISM; protein pellino homolog 1; RING-type E3 ubiquitin transferase pellino homolog 1
Gene Symbols PELI1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Pellino1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57162
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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