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Invitrogen™ Pellino 1 Polyclonal Antibody
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Catalog No. PIPA596982
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100 μL
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PIPA596982 100 μL
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Catalog No. PIPA596982 Supplier Invitrogen™ Supplier No. PA596982
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MFSPDQENHP SKAPVKYGEL IVLGYNGSLP NGDRGRRKSR FALFKRPKAN GVKPSTVHIA CTPQAAKAIS NKDQHSISYT LSRAQTVVVE YTHDSNTDMF QIGRSTESPI DFVVTDTVPG SQSNSDTQSV QSTISRFACR IICERNPPFT ARIYAAGFDS SKNIFLGEKA AKWKTSDGQM DGLTTNGVLV MHPRNGFTED SKPGIWREIS VCGNVFSLRE TRSAQQRGKM VEIETNQLQD GSLIDLCGAT; Positive Samples: Rat brain.

The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-Kappa-B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon; and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Pellino 1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.36 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PELI1
Gene Accession No. Q8C669, Q96FA3
Gene Alias 2810468L03Rik; A930031K15Rik; AA409794; AI586297; D11Ertd676e; E3 ubiquitin-protein ligase pellino homolog 1; Peli1; pellino 1; pellino E3 ubiquitin protein ligase 1; pellino homolog 1; pellino1; pellino-1; Pellino-related intracellular-signaling molecule; PRISM; protein pellino homolog 1; RING-type E3 ubiquitin transferase pellino homolog 1
Gene Symbols PELI1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human PELI1 (NP_0657022).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 305549
Target Species Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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