Invitrogen™ PEN2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110228

Catalog No. PIPA5110228

Description

Immunogen sequence: MNLERVSNEE KLNLCRKYYL GGFAFLPFLW LVNIFWFFRE AFLVPAYTEQ SQIKGYVWRS AVGFLFWVIV LTSWITIFQI YRPRWGALGD YLSFTIPLGT P.

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.

Specifications

• Antigen: PEN2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PSENEN
• Gene Alias: 1700023M09Rik; gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; liver regeneration-related protein LRRGT00140; LRRGT00140 mRNA; MDS033; MSTP064; Pen2; Pen-2; presenilin enhancer 2; presenilin enhancer 2 homolog; presenilin enhancer 2 homolog (C. elegans); presenilin enhancer gamma secretase subunit; presenilin enhancer gamma-secretase subunit; presenilin enhancer protein 2; presenilin enhancer, gamma-secretase subunit; Psenen; RGD1312037
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 292788, 55851, 66340
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q6QI68, Q9CQR7, Q9NZ42
• Gene Symbols: PSENEN
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-101 of human PEN2/PSENEN (NP_7588441).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG