Invitrogen™ PEN2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520302

Catalog No. PIPA520302

Description

A suggested positive control is A-20 cell lysate. PA5-20302 can be used with blocking peptide PEP-0427.

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.

Specifications

• Antigen: PEN2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PSENEN
• Gene Alias: 1700023M09Rik; gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; liver regeneration-related protein LRRGT00140; LRRGT00140 mRNA; MDS033; MSTP064; Pen2; Pen-2; presenilin enhancer 2; presenilin enhancer 2 homolog; presenilin enhancer 2 homolog (C. elegans); presenilin enhancer gamma secretase subunit; presenilin enhancer gamma-secretase subunit; presenilin enhancer protein 2; presenilin enhancer, gamma-secretase subunit; Psenen; RGD1312037
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 292788, 55851, 66340
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q6QI68, Q9CQR7, Q9NZ42
• Gene Symbols: PSENEN
• Immunogen: A 13 amino acid peptide from near the amino terminus of human PEN2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov