Invitrogen™ Pepsin A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536559

Catalog No. PIPA536559

Description

This antibody detects endogenous protein at a molecular weight of 42 kDa. Purity is >95% by SDS-PAGE.

Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. Pepsin A is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. Pepsin A is inhibited by ovUS-1, a uterine serpin.

Specifications

• Antigen: Pepsin A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PGA3
• Gene Alias: 1110035E17Rik; Pepf; pepsin A; pepsin A-3; Pepsin A-4; pepsin A-5; Pepsin F; pepsinogen 3, group I (pepsinogen A); pepsinogen 4, group I (pepsinogen A); pepsinogen 5, group I; pepsinogen 5, group I (pepsinogen A); pepsinogen A3; pepsinogen A4; pepsinogen A5; pepsinogen F; pepsinogen F protein; pepsinogen-3; Pepsinogen-4; pepsinogen-5; Pg5; PGA3; PGA4; PGA5
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5222, 58803, 60372, 643834, 643847
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P0DJD7, P0DJD8, P0DJD9, Q9D106
• Gene Symbols: PGA3, PGA4, PGA5
• Immunogen: Synthetic peptide corresponding to amino acids 281-330 of human Pepsin A.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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