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PGA5 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550549

Catalog No. PA550549


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Description

Description

The antibody detects endogenous levels of total Pepsin A protein.

PGA5: Pepsinogen 5, group I (pepsinogen A). Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor,pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. PGA5 is a member of the subfamily A1 within the pepsin family and is the predomit endopeptidase in the gastric juice of vertebrates.PGA5 is inhibited by ovUS-1, a uterine serpin.
Specifications

Specifications

PGA5
Polyclonal
Unconjugated
PGA5
Liquid
PGA5
Synthetic peptide corresponding to a region derived from internal residues of human Pepsinogen 5, group I (pepsinogen A)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
2.1 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
P0DJD9
PGA3, PGA4
Rabbit
IgG
100 μL
-20°C
Primary
5222
Documents
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