Invitrogen™ PER2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110098

Catalog No. PIPA5110098

Description

Immunogen sequence: GQPFDYSPIR FRARNGEYIT LDTSWSSFIN PWSRKISFII GRHKVRVGPL NEDVFAAHPC TEEKALHPSI QELTEQIHRL LLQPVPHSGS SGYGSLGSNG SHEHLMSQTS SSDSNGHEDS RRRRAEICKN GNKTKNRSHY SHESGEQKKK SVTEMQTNPP AEKKAVPAME KDSLGV.

PER2, also known as Period circadian protein homolog 2, is a mainly nuclear protein that shows nucleocytoplasmic shuttling which is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. PER2 belongs to the basic helix-loop-helix family of transcription factors and contains a PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. PER2 is a component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. This protein is thus essential for generating circadian rhythms and is a negative element in the circadian transcriptional loop which influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Expression of PER2 is fairly wide spread with strong expression in skeletal muscle and pancreas and slight expression in lung. Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS).

Specifications

• Antigen: PER2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Per2
• Gene Alias: circadian clock protein PERIOD 2; FASPS; FASPS1; hPER2; KIAA0347; mKIAA0347; mPer2; PER2; per2 {ECO:0000312; period 2; period circadian clock 2; period circadian protein 2; period circadian protein homolog 2; period circadian regulator 2; period homolog 2; RGD:61945}; rPER2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 63840, 8864
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.73 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: O15055, Q9Z301
• Gene Symbols: Per2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 390-565 of human PER2 (NP_0737281).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG