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Perforin Antibody (PRF1/2468), Janelia Fluor™ 549, Novus Biologicals™
SDP

Catalog No. NB008723 Shop All R&D Systems Products
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NB008723 0.1 mL
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Catalog No. NB008723 Supplier Novus Biologicals Supplier No. NBP275737JF549
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Description

Mouse Monoclonal Antibody

Perforin Monoclonal specifically detects Perforin in Human samples. It is validated for ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Perforin
Applications Immunohistochemistry, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone PRF1/2468
Conjugate Janelia Fluor 549
Dilution Immunohistochemistry, Immunohistochemistry-Paraffin
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias Cytolysin, FLH2, HPLH2, HPLH2lymphocyte pore forming protein, Lymphocyte pore-forming protein, MGC65093, P1PFN1, perforin 1 (pore forming protein), perforin-1, PFPcytolysin
Gene Symbols PRF1
Host Species Mouse
Immunogen Recombinant human Perforin protein fragment (around aa 413-552) (exact sequence is proprietary) (Uniprot: P14222)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Adaptive Immunity, Apoptosis, Immunology, Innate Immunity
Primary or Secondary Primary
Test Specificity Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG2b κ
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