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Invitrogen™ Perforin Monoclonal Antibody (CE2.10)
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Catalog No. PIMA125835
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50 μg
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PIMA125835 50 μg
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Catalog No. PIMA125835 Supplier Invitrogen™ Supplier No. MA125835
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Description

Mouse Monoclonal Antibody

MA1-25835 detects a band ~C66 kDa from the mouse T cell clone B6.1 (pos. control). This antibody does not detect human perforin by western blot.

Perforin is one of the major cytolytic proteins of cytolytic granules. Perforin is a cytolytic mediator and is stored in and released by cytoplasmic granules. Moreover, perforin is involved in immune defense against tumors and virus infections as mediated by cytotoxic lymphocytes. Perforin is a 555 amino acid protein with a 21 amino acid signal peptide, and has a molecular weight of 70 to 75 kD. Perforin is a pore forming protein with a mechanism of transmembrane channel formation similar to C9, and homology between perforin and C9 have been demonstrated. Studies show that perforin is expressed only in killer cell lines and not in helper T lymphocytes or other tumor cells tested. Perforin is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants of perforin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Perforin
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone CE2.10
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene PRF1
Gene Accession No. P10820, P14222
Gene Alias Cyta; Cytolysin; FLH2; HPLH2; lymphocyte pore forming protein; lymphocyte pore-forming protein; OMAK; OTTHUMP00000019759; P1; perforin 1; perforin 1 (pore forming protein); Perforin1; perforin-1; Pfn; PFN1; Pfp; PGFL; PIGF; PIGF-2; PLGF; pore forming protein; pore-forming protein; PRF1; Prf-1; PRF1 (pore forming protein 1); RATCYTA; RP11-710A11.3
Gene Symbols PRF1
Host Species Mouse
Immunogen Recombinant mouse perforin (aa. 98-534).
Purification Method IgG fraction
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18646, 5551
Target Species Human, Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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