Invitrogen™ Pericentrin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553498

Catalog No. PIPA553498

Description

Immunogen sequence: MEDLQNQFQK ELAEQRAELE KIFQDKNQAE RALRNLESHH QAAIEKLRED LQSEHGRCLE DLEFKFKESE KEKQLELENL QASYEDLKAQ SQEEIRRLWS QLDSARTSRQ ELSELHEQLL ARTSRVEDLE QLKQREKTQH ESELE Highest antigen sequence identity to the following orthologs: Mouse - 64%, Rat - 64%.

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.

Specifications

• Antigen: Pericentrin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PCNT
• Gene Alias: AW476095; C86676; KEN; kendrin; KIAA0402; m239Asp; m275Asp; MOPD2; PCN; Pcnt; PCNT2; PCNTB; PCTN2; Pericentrin; pericentrin (kendrin); pericentrin 2; pericentrin-2; pericentrin-250; pericentrin-360; pericentrin-380; pericentrin-B; SCKL4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5116
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O95613
• Gene Symbols: PCNT
• Immunogen: Recombinant protein corresponding to Human Pericentrin. Recombinant protein control fragment (Product #a href=.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov