Invitrogen™ Pericentrin Recombinant Rabbit Monoclonal Antibody (PSH0-66)

Catalog No.	Quantity
MA551929	100 μL

Catalog No. MA551929 Supplier Invitrogen™ Supplier No. MA551929

Description

Rabbit Recombinant Monoclonal Antibody

Sequence Similarities: 63% Mouse/No Cross with Rat. Tissue Specificity: Expressed in all tissues tested, including placenta, liver, kidney and thymus. Positive Control: HeLa cell lysate, HepG2 cell lysate, MCF7 cell lysate, K-562 cell lysate. Subcellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Predicted band size: 378 kDa.

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.

Specifications

• Antigen: Pericentrin
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: PSH0-66
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene: PCNT
• Gene Accession No.: O95613
• Gene Alias: AW476095; C86676; KEN; kendrin; KIAA0402; m239Asp; m275Asp; MOPD2; PCN; Pcnt; PCNT2; PCNTB; PCTN2; Pericentrin; pericentrin (kendrin); pericentrin 2; pericentrin-2; pericentrin-250; pericentrin-360; pericentrin-380; pericentrin-B; SCKL4
• Gene Symbols: PCNT
• Host Species: Rabbit
• Immunogen: Recombinant protein within human aa 201-600/3,336.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5116
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG