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Invitrogen™ Periostin Polyclonal Antibody
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Catalog No. PIPA582458
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100 μL
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PIPA582458 100 μL
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Catalog No. PIPA582458 Supplier Invitrogen™ Supplier No. PA582458
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GLFINHYPNG VVTVNCARII HGNQIATNGV VHVIDRVLTQ IGTSIQDFIE AEDDLSSFRA AAITSDILEA LGRDGHFTLF APTNEAFEKL PRGVLERIMG DKVASEALMK YHILNTLQCS ESIMGGAVFE TLEG Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 95%.

Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1(TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Periostin
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Postn
Gene Accession No. Q15063
Gene Alias A630052E07Rik; AI747096; fasciclin I-like; Fasciclin-I like; LOW QUALITY PROTEIN: periostin; MGC119510; MGC119511; OSF 2; Osf2; OSF-2; osteoblast specific factor 2; osteoblast specific factor 2 (fasciclin I-like); osteoblast-specific factor 2; PDLPOSTN; peri; periodontal ligament-specific periostin; periostin; periostin variant 1; periostin variant 2; periostin variant 3; periostin variant 4; periostin variant 5; periostin variant 6; periostin variant 7; periostin variant 8; periostin variant 9; periostin, osteoblast specific factor; periostin-like factor; Plf; PN; POSTN; POSTN protein; RP11 412K4.1; RP11-412K4.1
Gene Symbols Postn
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human POSTN. Recombinant protein control fragment (Product #RP-89721).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10631
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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