Invitrogen™ Periostin Recombinant Rabbit Monoclonal Antibody (JA63-40)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA532701

Catalog No. PIMA532701

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1(TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.

Specifications

• Antigen: Periostin
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q15063
• Gene Symbols: Postn
• Immunogen: Synthetic pepride within Human Perilipin-1 aa 11-60.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: JA63-40
• Conjugate: Unconjugated
• Gene: Postn
• Gene Alias: A630052E07Rik; AI747096; fasciclin I-like; Fasciclin-I like; LOW QUALITY PROTEIN: periostin; MGC119510; MGC119511; OSF 2; Osf2; OSF-2; osteoblast specific factor 2; osteoblast specific factor 2 (fasciclin I-like); osteoblast-specific factor 2; PDLPOSTN; peri; periodontal ligament-specific periostin; periostin; periostin variant 1; periostin variant 2; periostin variant 3; periostin variant 4; periostin variant 5; periostin variant 6; periostin variant 7; periostin variant 8; periostin variant 9; periostin, osteoblast specific factor; periostin-like factor; Plf; PN; POSTN; POSTN protein; RP11 412K4.1; RP11-412K4.1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 10631
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid