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Invitrogen™ Periplakin Polyclonal Antibody
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Catalog No. PIPA579856
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100 μg
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Catalog No. Quantity
PIPA579856 100 μg
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Catalog No. PIPA579856 Supplier Invitrogen™ Supplier No. PA579856
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human Hela whole cell, human A549 whole cell, human SW620 whole cell, human HepG2 whole cell, human SK-OV-3 whole cell, human PANC-1 whole cell, human SGC-7801 whole cell, rat lung tissue, mouse lung tissue. IHC: human lung cancer tissue, human oesophagus squama cancer tissue, human tonsil tissue. ICC/IF: A431 cell. Flow: U20S cell.

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Periplakin
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and 0.05mg sodium azide
Gene Ppl
Gene Accession No. O60437, Q9R269
Gene Alias 190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor protein; 195kDa protein; AW553870; KIAA0568; MGC134872; Periplakin; Ppl
Gene Symbols Ppl
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human Periplakin (1664-1701aa DTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVK).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19041, 302934, 5493
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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