Invitrogen™ PERK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120620

Catalog No. PIPA5120620

Description

Positive test controls include: Mouse thymus. The target is usually found in the following locations: Endoplasmic reticulum membrane, Single-pass type I membrane protein. Immunogen sequence: LTKNTTEKLQ PSSPKVYLYI QMQLCRKENL KDWMNGRCTI EERERSVCLH IFLQIAEAVE FLHSKGLMHR DLKPSNIFFT MDDVVKVGDF GLVTAMDQDE EEQTVLTPMP AYARHTGQVG TKLYMSPEQI HGNSYSHKVD IFSLGLILFE LLYPFSTQME RVRTLTDVRN LKFPPLFTQK YPCEYVMVQD MLSPSPMERP EAINIIENAV FEDLDFPGKT VLRQRSRSLS SSGTKHSRQS NNSHSPLPSN.

EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.

Specifications

• Antigen: PERK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EIF2AK3
• Gene Alias: 2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13666, 29702, 9451
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.99 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q9NZJ5, Q9Z1Z1, Q9Z2B5
• Gene Symbols: EIF2AK3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 867-1116 of human PERK (NP_004827.4).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG