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Invitrogen™ Perlecan Monoclonal Antibody (A76)
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Catalog No. CSI0017602
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400 μL
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CSI0017602 400 μL
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Catalog No. CSI0017602 Supplier Invitrogen™ Supplier No. CSI0017602
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Description

Mouse Monoclonal Antibody

CSI 001-76-02 is highly specific for perlecan. There is no evidence for cross-reactivity with other connective tissue proteins (vitronectin, fibronectin, elastin, collagen, laminin). CSI 001-76-02 cross-reacts with human thrombospondin. Other species have not been tested. CSI 001-76-02 has been successfully used in ELISA, immunohistochemistry and Western blotting techniques. CSI 001-76-02 can be used in immunoprecipitation, ELISA and immunostaining of frozen PLP-fixed sections of bovine and human tissues. CSI 001-76-02 is more sensitive than CSI 001-71-02 or CSI 001-74-02 in ELISA. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL.

Perlecan is a major heparan-sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth factors, perlecan has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Perlecan
Applications ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone A76
Concentration 1.01 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene HSPG2
Gene Accession No. P98160
Gene Alias AI852380; Basement membrane-specific heparan sulfate proteoglycan core protein; Endorepellin; endorepellin (domain V region); heparan sulfate proteoglycan 2; HSPG; Hspg2; LG3 peptide; LOC313641; Pcn; per; perlecan; perlecan (heparan sulfate proteoglycan 2); perlecan proteoglycan; PLC; PRCAN; RP11-132G19.2; SJA; SJS; SJS1
Gene Symbols HSPG2
Host Species Mouse
Immunogen Lysed bovine corneal endothelial.
Purification Method Protein A/G
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3339, 444872
Target Species Human, Bovine
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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