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Perlecan Monoclonal Antibody (A7L6), Invitrogen™

Catalog No. PIMA514641
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500 μL
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Catalog No. Quantity
PIMA514641 500 μL
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Catalog No. PIMA514641 Supplier Thermo Scientific Supplier No. MA514641

Description

Rat Monoclonal Antibody

MA5-14641 targets Perlecan in IF, IHC (F), and IHC (P, F) applications and shows reactivity with Bovine, Human, mouse, and Porcine samples. The MA5-14641 immunogen is mouse EHS laminin preparation.

Perlecan is a major heparan-sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth factors, perlecan has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Perlecan
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone A7L6
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene HSPG2
Gene Accession No. P98160, Q05793
Gene Alias AI852380; Basement membrane-specific heparan sulfate proteoglycan core protein; Endorepellin; endorepellin (domain V region); heparan sulfate proteoglycan 2; HSPG; Hspg2; LG3 peptide; LOC313641; Pcn; per; perlecan; perlecan (heparan sulfate proteoglycan 2); perlecan proteoglycan; PLC; PRCAN; RP11-132G19.2; SJA; SJS; SJS1
Gene Symbols HSPG2
Host Species Rat
Immunogen Murine EHS laminin preparation
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100517288, 15530, 3339, 444872
Target Species Bovine, Human, Mouse, Pig
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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