Invitrogen™ PERP Recombinant Rabbit Monoclonal Antibody (1O3L5)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA538148

Catalog No. PIMA538148

Description

Positive Samples: HepG2, BxPC-3, A-431, Mouse liver, Mouse kidney, Rat lung, Rat liver Immunogen sequence: LSFFALCGPQ MLVFLRVIGG LLALAAVFQI ISLVIYPVKY TQTFTLHANP AVTYIYNWAY GFGWAATIIL IGCAFFFCCL PNYEDDLLGN AKPRYFYTSA.

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.

Specifications

• Antigen: PERP
• Classification: Recombinant Monoclonal
• Concentration: 1.2 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q96FX8, Q9JK95
• Gene Symbols: PERP
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 94-193 of human PERP (Q96FX8).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 1O3L5
• Conjugate: Unconjugated
• Gene: PERP
• Gene Alias: 1110017A08Rik; dJ496H19.1; HGNC:17637; KCP1; KCP-1; keratinocyte associated protein 1; keratinocyte-associated protein 1; keratinocytes associated protein 1; KRTCAP1; p53 apoptosis effector related to PMP22; p53 apoptosis effector related to PMP-22; p53 apoptosis-associated target; p53-induced protein PIGPC1; PERP; PERP, TP53 apoptosis effector; PIGPC1; RP3-496H19.1; THW; Transmembrane protein THW
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 292949, 64058, 64065
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid