Invitrogen™ PEX13 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556942

Catalog No. PIPA556942

Description

Immunogen sequence: SADLGPTLMT RPGQPALTRV PPPILPRPSQ QTGSSSVNTF RPAYSSFSSG YGAYGNSFYG GYSPYSYGYN GLGYNRLRVD DLPPSRFVQQ AEESSRGA Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 92%.

PEX13 (Peroxisomal Biogenesis Factor 13) is a gene located on chromosome 2p15 that encodes a peroxisomal membrane protein essential for the biogenesis and function of peroxisomes, which are cellular organelles involved in lipid metabolism and detoxification of reactive oxygen species. PEX13 is a component of the peroxisomal import machinery that specifically recognizes and binds to peroxisomal targeting signal 1 (PTS1) containing proteins, facilitating their import into the peroxisome matrix. Mutations in the PEX13 gene can lead to Zellweger spectrum disorders, a group of peroxisome biogenesis disorders (PBDs) characterized by defects in multiple peroxisomal metabolic pathways, leading to severe developmental issues, neurological deficits, and often early lethality. Studies of PEX13 have helped elucidate the mechanisms of peroxisomal protein import and the broader implications of peroxisomal dysfunction in human disease.

Specifications

• Antigen: PEX13
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PEX13
• Gene Alias: NALD; PBD11A; PBD11B; Peroxin-13; peroxisomal biogenesis factor 13; peroxisomal membrane protein PEX13; peroxisome biogenesis factor 13; Pex13; ZWS
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5194
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q92968
• Gene Symbols: PEX13
• Immunogen: Recombinant protein corresponding to Human PEX13. Recombinant protein control fragment (Product #RP-95803).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG