Invitrogen™ PEX5 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5143252

Catalog No. PIPA5143252

Description

Additional Information: This antibody is expected to recognize all reported isoforms (NP_001124495.1; NP_000310.2; NP_001124496.1; NP_001124497.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.

Specifications

• Antigen: PEX5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pex5
• Gene Alias: AW212715; ESTM1; LOW QUALITY PROTEIN: peroxisomal biogenesis factor 5; PBD2A; PBD2B; peroxin 5; peroxin-5; peroxisomal biogenesis factor 5; peroxisomal C-terminal targeting signal import receptor; peroxisomal targeting signal 1 (SKL type) receptor; peroxisomal targeting signal 1 receptor; peroxisomal targeting signal 1 receptor; peroxisomal biogenesis factor 5; peroxisomal targeting signal import receptor; peroxisomal targeting signal receptor 1; peroxisome biogenesis factor 5; peroxisome receptor 1; PEX5; Pex5_predicted; PTS1 BP; PTS1 receptor; PTS1-BP; PTS1R; Pxr1; PXR1P; RCDP5; X83306
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 5830
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P50542
• Gene Symbols: Pex5
• Immunogen: Peptide with sequence C-QHTASDFVAKVDDPK.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG