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Invitrogen™ PEX5 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA588585
Description
Immunogen sequence: WQYLGTTQAE NEQELLAISA LRRCLELKPD NQTALMALAV SFTNESLQRQ ACETLRDWLR YTPAYAHLVT PAEEGAGGAG LGPSKRILGS LLSDSLFLEV KELFLAAVRL DPTSIDPDVQ CGLGVLFNLS GEYDKAVDCF TAALSVRPND YLLWNKLGAT LANGNQSEEA VAAYRRALEL QPGYIRSRYN LGISCINLGA HREAVEHFLE ALNMQRKSRG PRGEGGAMSE NIWSTLRLAL SMLGQSDAYG AADARDLSTL LTMFGLPQ; Positive Samples: U-251MG, HepG2, 293T, HeLa, Mouse brain, Mouse kidney, Mouse liver; Cellular Location: Cytoplasm, Peripheral membrane protein, Peroxisome membrane.
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
Specifications
PEX5 | |
Polyclonal | |
Unconjugated | |
Pex5 | |
AW212715; ESTM1; LOW QUALITY PROTEIN: peroxisomal biogenesis factor 5; PBD2A; PBD2B; peroxin 5; peroxin-5; peroxisomal biogenesis factor 5; peroxisomal C-terminal targeting signal import receptor; peroxisomal targeting signal 1 (SKL type) receptor; peroxisomal targeting signal 1 receptor; peroxisomal targeting signal 1 receptor; peroxisomal biogenesis factor 5; peroxisomal targeting signal import receptor; peroxisomal targeting signal receptor 1; peroxisome biogenesis factor 5; peroxisome receptor 1; PEX5; Pex5_predicted; PTS1 BP; PTS1 receptor; PTS1-BP; PTS1R; Pxr1; PXR1P; RCDP5; X83306 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
19305, 312703, 5830 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
ELISA, Western Blot, Immunocytochemistry | |
2.13 mg/mL | |
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3 | |
O09012, P50542, Q2M2R8 | |
Pex5 | |
Recombinant fusion protein containing a sequence corresponding to amino acids 364-631 of human PEX5 (NP_0003102). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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