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Tocris Bioscience™ Pexacerfont
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Catalog No. 645150
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Catalog No. Quantity
64-515-0 50 mg
64-511-0 10 mg
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Catalog No. 64-515-0 Supplier Tocris Bioscience™ Supplier No. 6451/50
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Description

Potent and selective CRF1 antagonist; anxiolytic

Pexacerfont is a potent and selective corticotropin-releasing factor 1 receptor (CRF1) antagonist (IC50 = 6.1 nM). Displays >150 fold selectivity for CRF1 over CRF2b. Inhibits CRF-mediated adrenocorticotropic hormone (ACTH) release from pituitary cell culture (IC50 = 129 nM). Displays anxiolytic effects in rat behavioral paradigms.

Specifications

Chemical Name or Material 8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine
CAS 459856-18-9
Quantity 50 mg
Molecular Formula C18H24N6O
Formula Weight 340.43
Purity 98%
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