Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic Compounds
  5. Benzenoids
  6. Benzene and substituted derivatives
  7. Benzoic acids and derivatives
  8. Halobenzoic acids and derivatives
  9. 4-halobenzoic acids and derivatives
  10. PF 04418948, Tocris Bioscience™

PF 04418948, Tocris Bioscience™

Click to view available options
Quantity:
10mg
50mg
This item is not returnable. View return policy
1078166-57-0
C23H20FNO5
409.413
LWJGMYMNSNVCEM-UHFFFAOYSA-N
unii-i7z38e70vf,d0s5ef,prostaglandin e2 ep2 subtype antagonist endometriosis , pfizer,1-4-fluorobenzoyl-3-6-methoxynaphthalen-2-yl oxymethyl azetidine-3-carboxylic acid,1-4-fluorobenzoyl-3-6-methoxy-2-naphthalenyl oxy methyl-3-azetidinecarboxylic acid,1-4-fluorobenzoyl-3-6-methoxy-2-naphthyl oxy methyl azetidine-3-carboxylic acid,3-azetidinecarboxylic acid, 1-4-fluorobenzoyl-3-6-methoxy-2-naphthalenyl oxy methyl
25114442
1-(4-fluorobenzoyl)-3-[(6-methoxynaphthalen-2-yl)oxymethyl]azetidine-3-carboxylic acid
COC1=CC2=C(C=C1)C=C(C=C2)OCC3(CN(C3)C(=O)C4=CC=C(C=C4)F)C(=O)O
This item is not returnable. View return policy
1078166-57-0
C23H20FNO5
409.413
LWJGMYMNSNVCEM-UHFFFAOYSA-N
unii-i7z38e70vf,d0s5ef,prostaglandin e2 ep2 subtype antagonist endometriosis , pfizer,1-4-fluorobenzoyl-3-6-methoxynaphthalen-2-yl oxymethyl azetidine-3-carboxylic acid,1-4-fluorobenzoyl-3-6-methoxy-2-naphthalenyl oxy methyl-3-azetidinecarboxylic acid,1-4-fluorobenzoyl-3-6-methoxy-2-naphthyl oxy methyl azetidine-3-carboxylic acid,3-azetidinecarboxylic acid, 1-4-fluorobenzoyl-3-6-methoxy-2-naphthalenyl oxy methyl
25114442
1-(4-fluorobenzoyl)-3-[(6-methoxynaphthalen-2-yl)oxymethyl]azetidine-3-carboxylic acid
COC1=CC2=C(C=C1)C=C(C=C2)OCC3(CN(C3)C(=O)C4=CC=C(C=C4)F)C(=O)O

Description

Potent and selective EP2 receptor antagonist

Potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).
Quantity 10mg
Formula Weight 409.41
Percent Purity >99%
Chemical Name or Material PF 04418948

Safety and Handling

Recommended Storage : Store at -20°C