Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

PF 04418948, Tocris Bioscience™

Click to view available options
Quantity:
10mg
50mg
This item is not returnable. View return policy
1078166-57-0
C23H20FNO5
409.413
LWJGMYMNSNVCEM-UHFFFAOYSA-N
unii-i7z38e70vf,d0s5ef,prostaglandin e2 ep2 subtype antagonist endometriosis , pfizer,1-4-fluorobenzoyl-3-6-methoxynaphthalen-2-yl oxymethyl azetidine-3-carboxylic acid,1-4-fluorobenzoyl-3-6-methoxy-2-naphthalenyl oxy methyl-3-azetidinecarboxylic acid,1-4-fluorobenzoyl-3-6-methoxy-2-naphthyl oxy methyl azetidine-3-carboxylic acid,3-azetidinecarboxylic acid, 1-4-fluorobenzoyl-3-6-methoxy-2-naphthalenyl oxy methyl
25114442
1-(4-fluorobenzoyl)-3-[(6-methoxynaphthalen-2-yl)oxymethyl]azetidine-3-carboxylic acid
COC1=CC2=C(C=C1)C=C(C=C2)OCC3(CN(C3)C(=O)C4=CC=C(C=C4)F)C(=O)O
This item is not returnable. View return policy
1078166-57-0
C23H20FNO5
409.413
LWJGMYMNSNVCEM-UHFFFAOYSA-N
unii-i7z38e70vf,d0s5ef,prostaglandin e2 ep2 subtype antagonist endometriosis , pfizer,1-4-fluorobenzoyl-3-6-methoxynaphthalen-2-yl oxymethyl azetidine-3-carboxylic acid,1-4-fluorobenzoyl-3-6-methoxy-2-naphthalenyl oxy methyl-3-azetidinecarboxylic acid,1-4-fluorobenzoyl-3-6-methoxy-2-naphthyl oxy methyl azetidine-3-carboxylic acid,3-azetidinecarboxylic acid, 1-4-fluorobenzoyl-3-6-methoxy-2-naphthalenyl oxy methyl
25114442
1-(4-fluorobenzoyl)-3-[(6-methoxynaphthalen-2-yl)oxymethyl]azetidine-3-carboxylic acid
COC1=CC2=C(C=C1)C=C(C=C2)OCC3(CN(C3)C(=O)C4=CC=C(C=C4)F)C(=O)O

Potent and selective EP2 receptor antagonist

Potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).
Quantity 50mg
Formula Weight 409.41
Percent Purity >99%
Chemical Name or Material PF 04418948

Recommended Storage : Store at -20°C