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  5. Tocris Bioscience™ PF 04991532

Tocris Bioscience™ PF 04991532

Catalog No. 63455
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Catalog No. 63455 Supplier Tocris Bioscience™ Supplier No. 6345/5
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Description

Potent hepatoselective glucokinase activator

PF 04991532 is a potent hepatoselective glucokinase activator (EC50 = 90 nM). Exhibits >50-fold liver to pancreas ratio of tissue distribution. Reduces fasting and postprandial glucose levels with no hypoglycemia in a rat diabetes model.

Specifications

Chemical Name or Material 6-[[(2 S)-3-Cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1 H-imidazol-1-yl]propyl]amino]-3-pyridinecarboxylic acid
CAS 1215197-37-7
Assay Percent Range >98%
Quantity 5 mg
Target Glucokinase/GCK
Molecular Formula C18H19F3N4O3
Formula Weight Observed MW: 396.36
Purity 98%
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