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  5. Tocris Bioscience™ PF 05089771

Tocris Bioscience™ PF 05089771
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Catalog No. 593150
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Catalog No. Quantity
59-315-0 50 mg
59-311-0 10 mg
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Catalog No. 59-315-0 Supplier Tocris Bioscience™ Supplier No. 5931/50
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Description

Potent and selective Nav1.7 channel blocker

PF 05089771 is a potent and selective Nav1.7 channel blocker (IC50 = 8, 11 and 171 nM for mouse, human and rat Nav1.7, respectively). Exhibits selectivity for Nav1.7 over other Nav1 channels (IC50 values are 0.11, 0.16, 0.85, 10, 11 and 25 μM for Nav1.2, Nav1.6, Nav1.1, Nav1.4, Nav1.3 and Nav1.5, respectively). Also exhibits selectivity over a panel of 81 other ion channels, receptors, enzymes and transporters. Blocks spontaneous firing of inherited erythromelalgia (IEM)-derived iPSC sensory neurons in vitro.

Specifications

Chemical Name or Material 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate
CAS 1430806-04-4
Quantity 50 mg
Target Voltage-gated Sodium Channel Blockers
Molecular Formula C18H12Cl2FN5O3S2.C7H8O3S
Formula Weight 672.56
Purity >98%
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