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  5. Tocris Bioscience™ PF 05175157

Tocris Bioscience™ PF 05175157
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Catalog No. 579050
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10 mg
50 mg
Catalog No. Quantity
57-905-0 50 mg
57-901-0 10 mg
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Catalog No. 57-905-0

Supplier: Tocris Bioscience™ 5790/50

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Description

Acetyl-CoA carboxylase (ACC) 1 and 2 inhibitor

PF 05175157 is an potent acetyl-CoA carboxylase (ACC) 2 and 1 inhibitor (IC50 values are 45 and 98 nM, respectively). Reduces hepatic and skeletal muscle malonyl-CoA levels in rats. Also inhibits hepatic de novo lipogenesis and reduces whole body respiratory exchange ratio in rats. Orally bioavailable.

Specifications

Chemical Name or Material 1,4-Dihydro-1′-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4′-piperidin]-7(6H)-one
CAS 1301214-47-0
Quantity 50 mg
Target Additional Lipid Metabolism Compounds
Molecular Formula C23H27N5O2
Formula Weight 405.49
Purity >98%
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