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  5. Tocris Bioscience™ PF 05190457

Tocris Bioscience™ PF 05190457
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Catalog No. 635025
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25 mg
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Catalog No. Quantity
63-502-5 25 mg
63-505 5 mg
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Catalog No. 63-502-5 Supplier Tocris Bioscience™ Supplier No. 6350/25
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Description

High affinity and selective ghrelin receptor inverse agonist

PF 05190457 is a high affinity and selective ghrelin receptor inverse agonist (Kd = 3 nM). Exhibits selectivity for ghrelin receptors over a panel of other targets. Increases intracellular Ca2+ concentration in and insulin secretion from human islets in vitro. Increases gastric afferent nerve activity in a rat ex vivo stomach preparation.

Specifications

Chemical Name or Material 1-[2-[(1R)-2,3-Dihydro-5-(6-methyl-4-pyrimidinyl)-1H-inden-1-yl]-2,7-diazaspiro[3,5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)ethanone
CAS 1334782-79-4
Assay Percent Range >98%
Quantity 25 mg
Molecular Formula C29H32N6OS
Formula Weight Observed MW: 512.67
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