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  5. Tocris Bioscience™ PF 06260933 dihydrochloride

Tocris Bioscience™ PF 06260933 dihydrochloride
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Catalog No. 575250
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10 mg
50 mg
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Catalog No. 57-525-0

Supplier: Tocris Bioscience™ 5752/50

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Description

MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK

PF 06260933 dihydrochloride is a MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.

Specifications

Chemical Name or Material 5-(4-Chlorophenyl)-[3,3 '-bipyridine]-6,6 '-diamine dihydrochloride
CAS 1883548-86-4
Synonym EC 2.7.11, EC 2.7.11.1, FLH21957, FLJ10410, hepatocyte progenitor kinase-like/germinal center kinase-like kinase, HGKFLJ20373, HPK/GCK-like kinase HGK, KIAA0687, MAP4K4, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, MEKKK4, mitogen-activa
Quantity 50 mg
Target HGK/MAP4K4
Molecular Formula C16H13ClN40.2 HCl
Formula Weight 369.68
Purity 98%
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