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PF 06281355, >98%, Tocris Bioscience™
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Quantity:
10 mg
50 mg
Description
Selective myeloperoxidase (MPO) inhibitor (IC50 = 1.5 μM in LPS-stimulated human whole blood). Selective for MPO over a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibits MPO activity in peritoneal lavage and plasma in a murine peritonitis model. Also reduces lung edema in a murine pulmonary immune complex vasculitis model. Orally bioavailable.
Specifications
Refractive Index | Store at RT |
Linear Formula | C14H15N3O4S |
Quantity | 10 mg |
Solubility Information | Soluble to 20mM in DMSO with gentle warming |
Formula Weight | 321.35 |
Chemical Name or Material | 6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide |
Grade | >98% |
Safety and Handling
Recommended Storage : Store at RT