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PF 06281355, >98%, Tocris Bioscience™

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Quantity:
10mg
50mg
This item is not returnable. View return policy
1435467-38-1
C14H15N3O4S
321.351
LJBUZOGABRDGBR-UHFFFAOYSA-N
2-6-2,5-dimethoxyphenyl-4-oxo-2-sulfanylidene-3h-pyrimidin-1-yl acetamide,6-2,5-dimethoxyphenyl-3,4-dihydro-4-oxo-2-thioxo-1 2h-pyrimidineacetamide
71568997
2-[6-(2,5-dimethoxyphenyl)-4-oxo-2-sulfanylidenepyrimidin-1-yl]acetamide
COC1=CC(=C(C=C1)OC)C2=CC(=O)NC(=S)N2CC(=O)N
This item is not returnable. View return policy
1435467-38-1
C14H15N3O4S
321.351
LJBUZOGABRDGBR-UHFFFAOYSA-N
2-6-2,5-dimethoxyphenyl-4-oxo-2-sulfanylidene-3h-pyrimidin-1-yl acetamide,6-2,5-dimethoxyphenyl-3,4-dihydro-4-oxo-2-thioxo-1 2h-pyrimidineacetamide
71568997
2-[6-(2,5-dimethoxyphenyl)-4-oxo-2-sulfanylidenepyrimidin-1-yl]acetamide
COC1=CC(=C(C=C1)OC)C2=CC(=O)NC(=S)N2CC(=O)N

Selective myeloperoxidase (MPO) inhibitor

Selective myeloperoxidase (MPO) inhibitor (IC50 = 1.5 μM in LPS-stimulated human whole blood). Selective for MPO over a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibits MPO activity in peritoneal lavage and plasma in a murine peritonitis model. Also reduces lung edema in a murine pulmonary immune complex vasculitis model. Orally bioavailable.
Refractive Index Store at RT
Quantity 10mg
Linear Formula C14H15N3O4S
Solubility Information Soluble to 20mM in DMSO with gentle warming
Formula Weight 321.35
Grade >98%
Chemical Name or Material 6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide

Recommended Storage : Store at RT