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Tocris Bioscience™ PF 06424439
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Catalog No. 63485
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Catalog No.
63-485 5mg
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Catalog No. 63-485 Supplier Tocris Bioscience™ Supplier No. 6348/5
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Description

Potent and selective DGAT2 inhibitor

PF 06424439 is a potent and selective DGAT2 inhibitor (IC50 = 14 nM). Exhibits no significant activity at MGAT1-3 or DGAT1. Reduces triglyderide synthesis in human hepatocytes in vitro. Reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model. Orally bioavailable.

Specifications

Chemical Name or Material [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinylmethanone methanesulfonate
CAS 1469284-79-4
Assay Percent Range >98%
Quantity 5 mg
Molecular Formula C22H26ClN7O.CH4O3S
Formula Weight Observed MW: 536.05
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