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Tocris Bioscience™ PF 06726304 acetate
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Catalog No. 616910
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10 mg
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61-691-0 10 mg
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Catalog No. 61-691-0 Supplier Tocris Bioscience™ Supplier No. 6169/10
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Description

Highly potent and SAM-competitive EZH2 inhibitor

PF 06726304 acetate is a highly potent and SAM-competitive EZH2 lysine methyltransferase inhibitor (IC50 = 0.7 nM). Inhibits proliferation of Karpas-422 cells (non-Hodgkin's lymphoma) in vitro, and halts tumor growth and reduces intratumoral H3K27Me3 levels in mice.

Specifications

Chemical Name or Material PF 06726304 acetate
Synonym 5,8-Dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoquinolinone acetate
Quantity 10 mg
Solubility Soluble to 100mM in DMSO and to 100mM in ethanol
Molecular Formula C22H21Cl2N3O3.C2H4O2
Formula Weight 506.38
Physical Form Solid
Color White
Product Type Bioactive Small Molecule
Purity >97%

For Research Use Only.

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