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  5. Tocris Bioscience™ PF 3758309 dihydrochloride

Tocris Bioscience™ PF 3758309 dihydrochloride
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Catalog No. p-7121024
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60-051-0 10 mg
60-055-0 50 mg
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Catalog No. 60-051-0 Supplier Tocris Bioscience™ Supplier No. 6005/10
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Description

Potent PAK4 inhibitor; orally available

PF 3758309 dihydrochloride is a potent PAK4 inhibitor (IC50 = 1.3 nM; Kd = 2.7 nM). Inhibits proliferation and anchorage-independent growth of a panel of tumor cell lines in vitro. Suppresses growth of human HCT116 and A549 tumor cell xenografts in mice. Orally available.

Specifications

Chemical Name or Material PF 3758309 Dihydrochloride
Synonym N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide dihydrochloride
Quantity 10 mg
Solubility Soluble to 100mM in water and to 100mM in DMSO
Molecular Formula C25H30N8OS.2HCl
Formula Weight 563.55
Physical Form Solid
Color Off-white
Product Type Bioactive Small Molecule
Purity >98%

For Research Use Only.

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