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  5. Tocris Bioscience™ PF 5274857 hydrochloride

Tocris Bioscience™ PF 5274857 hydrochloride
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Catalog No. 526250
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50 mg
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Catalog No. Quantity
52-625-0 50 mg
52-621-0 10 mg
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Catalog No. 52-625-0 Supplier Tocris Bioscience™ Supplier No. 5262/50
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Description

High affinity and selective Smoothened (Smo) receptor antagonist

PF 5274857 hydrochloride is a high affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM). Exhibits >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. Inhibits Shh-induced Hedgehog signaling in MEF cells. Induces tumor regression in a medulloblastoma allograft mouse model. Orally available and brain penetrant.

Specifications

Quantity 50 mg
Product Type PF 5274857 hydrochloride
Purity >98%
Molecular Weight (g/mol) 473.42
Inhibitors PF 5274857 hydrochloride

For Research Use Only

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