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Tocris Bioscience™ PF 5274857 hydrochloride

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Quantity:
10 mg
50 mg
Description
PF 5274857 hydrochloride is a high affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM). Exhibits >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. Inhibits Shh-induced Hedgehog signaling in MEF cells. Induces tumor regression in a medulloblastoma allograft mouse model. Orally available and brain penetrant.
Specifications
Specifications
Quantity | 50 mg |
Product Type | PF 5274857 hydrochloride |
Purity | >98% |
Molecular Weight (g/mol) | 473.42 |
Inhibitors | PF 5274857 hydrochloride |
For Research Use Only
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