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  5. Tocris Bioscience™ PF 543 hydrochloride

Tocris Bioscience™ PF 543 hydrochloride

Catalog No. 575410
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Catalog No. 575410 Supplier Tocris Bioscience™ Supplier No. 5754/10
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Description

Potent and selective SphK1 inhibitor

PF 543 hydrochloride is a potent and selective SphK1 inhibitor (IC50 = 2 nM; Ki = 3.6 nM). Exhibits >100-fold selectivity for Sphk1 over Sphk2. Also exhibits >5,000 fold selectivity over S1P1-5 receptors and 48 protein and lipid kinases. Attenuates proliferation and induces necrosis in human colorectal cancer cells in vitro. Suppresses HCT-116 tumor xenograft growth in mice. Also reduces sickling, hemolysis and inflammation in a transgenic mouse model of sickle cell disease.

Specifications

Chemical Name or Material (2R)-1-[[(4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol hydrochloride
CAS 1706522-79-3
Quantity 10 mg
Target Sphingosine Kinase Inhibitors
Molecular Formula C27H31NO4S.HCl
Formula Weight 502.07
Purity >98%
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