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Tocris Bioscience™ PFI 7

Catalog No. 796050
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79-605-0 50 mg
79-601-0 10 mg
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Catalog No. 79-605-0 Supplier Tocris Bioscience™ Supplier No. 7960/50
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Description

Selective GID4 antagonist

PFI 7 is a selective GID4 antagonist (Kd = 80 nM by SPR assays and EC50 = 0.6 μM by cell-based NanoBRET). PFI 7 binds within the ?-barrel of GID4 substrate binding pocket, disrupting its interaction with the canonical Pro/N-degron peptide in live cells. It alters protein levels of several proteins including RNA helicases as measured by quantitative proteomics.

Specifications

Chemical Name or Material N-((1s,4s)-4-(1H-Benzo[d]imidazol-2-yl)cyclohexyl)-2-(((1H-indol-2-yl)methyl)amino)acetamide dihydrochloride
Quantity 50 mg
Target Ubiquitin Ligase (E3) Inhibitors
Molecular Formula C24H27N5O.2HCl
Purity 0.98
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