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PFKFB1/PFKFB4 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA5101180
Encompass
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PIPA5101180 100 μL
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Catalog No. PIPA5101180 Supplier Thermo Scientific Supplier No. PA5101180

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PFKFB1/4.

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PFKFB1/PFKFB4
Applications Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Pfkfb4
Gene Accession No. P07953, P16118, P25114, P70266, Q16877, Q6DTY7
Gene Alias 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ase 4; 6PF-2-K/Fru-2,6-P2ase liver isozyme; 6PF-2-K/Fru-2,6-P2ase testis-type isozyme; 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; bifunctional enzyme with kinase and biphosphatase activities; C230090D14; F6PK; Fructose-2,6-bisphosphatase; fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase; HL2K; PFK/FBPase 1; PFK/FBPase 4; PFK-2/FBPase-2 gene A; Pfkfb01; Pfkfb1; Pfkfb4; PFRX
Gene Symbols Pfkfb1, Pfkfb4
Host Species Rabbit
Immunogen A synthesized peptide derived from human PFKFB1(Accession P16118), corresponding to amino acid residues I329-I379.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18639, 24638, 270198, 5207, 5210, 54283
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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