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Invitrogen™ PFKFB3 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5121047
This item is not returnable.
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Description
Positive test controls include: HeLa, HCT116, Mouse brain, Rat brain. Immunogen sequence: TRERRHMILH FAKENDFKAF FIESVCDDPT VVASNIMEVK ISSPDYKDCN SAEAMDDFMK RISCYEASYQ PLDPDKCDRD LSLIKVIDVG R.
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specifications
PFKFB3 | |
Polyclonal | |
Unconjugated | |
PFKFB3 | |
6-biphosphatase 3; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme; 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; E330010H22Rik; Fructose-2; Fructose-2,6-bisphosphatase; fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase; inducible 6-phosphofructo-2-kinase; inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; IPFK2; iPFK-2; PFK/FBPase 3; PFK2; PFKFB3; RB2K; renal carcinoma antigen NY-REN-56; RP11-298K24.3; uPFK-2 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
117276, 170768, 5209 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
ELISA, Immunohistochemistry (Paraffin), Western Blot | |
0.85 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
O35552, Q16875 | |
PFKFB3 | |
Recombinant fusion protein containing a sequence corresponding to amino acids 130-220 of human PFKFB3 (NP_004557.1). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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