PFKFB1/PFKFB4 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5101180

Catalog No. PIPA5101180

Description

Antibody detects endogenous levels of total PFKFB1/4.

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene.

Specifications

• Antigen: PFKFB1/PFKFB4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pfkfb4
• Gene Alias: 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ase 4; 6PF-2-K/Fru-2,6-P2ase liver isozyme; 6PF-2-K/Fru-2,6-P2ase testis-type isozyme; 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; bifunctional enzyme with kinase and biphosphatase activities; C230090D14; F6PK; Fructose-2,6-bisphosphatase; fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase; HL2K; PFK/FBPase 1; PFK/FBPase 4; PFK-2/FBPase-2 gene A; Pfkfb01; Pfkfb1; Pfkfb4; PFRX
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18639, 24638, 270198, 5207, 5210, 54283
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P07953, P16118, P25114, P70266, Q16877, Q6DTY7
• Gene Symbols: Pfkfb1, Pfkfb4
• Immunogen: A synthesized peptide derived from human PFKFB1(Accession P16118), corresponding to amino acid residues I329-I379.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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