Invitrogen™ PGA5 Monoclonal Antibody (2C1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA515558

Catalog No. PIMA515558

Description

MA5-15558 targets PGA5 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples. The MA5-15558 immunogen is purified recombinant fragment of human PGA5 expressed in E. Coli. MA5-15558 detects PGA5 which has a predicted molecular weight of approximately 42kDa.

PGA5: Pepsinogen 5, group I (pepsinogen A). Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. PGA5 is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. PGA5 is inhibited by ovUS-1, a uterine serpin.

Specifications

• Antigen: PGA5
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Ascites with 0.03% sodium azide
• Gene Accession No.: P0DJD9
• Gene Symbols: Pga5
• Immunogen: Purified recombinant fragment of human PGA5 expressed in E. Coli.
• Regulatory Status: RUO
• Gene ID (Entrez): 5222
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 2C1
• Conjugate: Unconjugated
• Gene: Pga5
• Gene Alias: 1110035E17Rik; Pepf; pepsin A; pepsin A-5; Pepsin F; Pepsinogen 5; pepsinogen 5, group I; pepsinogen 5, group I (pepsinogen A); pepsinogen A; pepsinogen A precursor; pepsinogen A5; pepsinogen F; pepsinogen F protein; pepsinogen precursor; pepsinogen-5; Pg5; PGA; PGA3; PGA4; PGA5
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov