Invitrogen™ PGA5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588884

Catalog No. PIPA588884

Description

Immunogen sequence: VDEQPLENYL DMEYFGTIGI GTPAQDFTVV FDTGSSNLWV PSVYCSSLAC TNHNRFNPED SSTYQSTSET VSITYGTGSM TGILGYDTVQ VGGISDTNQI FGLSETEPGS FLYYAPFD; Positive Samples: U-87MG, HT-29, 293T, Mouse brain, Mouse stomach, Rat brain.

PGA5: Pepsinogen 5, group I (pepsinogen A). Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. PGA5 is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. PGA5 is inhibited by ovUS-1, a uterine serpin.

Specifications

• Antigen: PGA5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pga5
• Gene Alias: 1110035E17Rik; Pepf; pepsin A; pepsin A-5; Pepsin F; Pepsinogen 5; pepsinogen 5, group I; pepsinogen 5, group I (pepsinogen A); pepsinogen A; pepsinogen A precursor; pepsinogen A5; pepsinogen F; pepsinogen F protein; pepsinogen precursor; pepsinogen-5; Pg5; PGA; PGA3; PGA4; PGA5
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5222, 58803, 60372
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.66 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P0DJD9, Q9D106
• Gene Symbols: Pga5
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 63-180 of human PGA5 (NP_0550391).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG