Invitrogen™ PGC Monoclonal Antibody (90/11)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA183392

Catalog No. PIMA183392

Description

Mouse anti Human pepsinogen II antibody, clone 90/10 is specific for human pepsinogen II. Less than 1% reactivity has been observed with human pepsinogen I (isozymogens 2-5), porcine pepsinogen, gastrin I, somatostatin, peptide YY and bombesin.

Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity, and although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. The amino acid composition of Pepsin C differs from those of pepsinogen and pepsin especially in the content of basic amino acids, glutamic acid, aspartic acid, leucine and isoleucine.

Specifications

• Antigen: PGC
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: Citric acid, PBS with <0.1% sodium azide
• Gene Accession No.: P20142
• Gene Symbols: Pgc
• Immunogen: Human pepsinogen II.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA
• Clone: 90/11
• Conjugate: Unconjugated
• Gene: Pgc
• Gene Alias: 2210410L06Rik; Gastricsin; pep carboxylase; PEPC; pepcase; pepsin C; pepsinogen C; pepsinogen group II; PG1; Pg-1; Pgc; PGII; preprogastricsin; progastricsin; progastricsin (pepsinogen C); Upg1; Upg-1; Urinary pepsinogen 1
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 5225
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov