Invitrogen™ PPARGC1A Polyclonal Antibody

Catalog No.	Quantity
PIPA572948	100 μL

Catalog No. PIPA572948 Supplier Invitrogen™ Supplier No. PA572948

Description

Rabbit Polyclonal Antibody

Expected from sequence similarity: Mouse. In IHC-P, staining is very strong in the nucleus with some cytoplasmic staining. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

PGC1 alpha is a transcriptional coactivator that regulates the genes involved in energy metabolism. It interacts with PPARgamma, which permits it's interaction with multiple transcription factors. PGC-1 Alpha can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. It may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

Specifications

• Antigen: PPARGC1A
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, RNA Immunoprecipitation, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide
• Gene: Ppargc1a
• Gene Accession No.: O70343, Q865B6, Q9QYK2, Q9UBK2
• Gene Alias: A830037N07Rik; ENSMUSG00000079510; Gm11133; I79_015506; LEM6; Ligand effect modulator 6; ligand effect modulator-6; L-PGC-1alpha; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; Pgc1; PGC-1; pgc-1 alpha; PGC-1(alpha); PGC1A; PGC-1alpha; PGC-1-alpha; Pgc-1alphaa; PGC-1v; Pgco1; PPAR gamma coactivator variant form; PPAR Gamma Coactivator-1; PPARG coactivator 1 alpha; PPARgamma coactivator 1alpha; PPAR-gamma coactivator 1-alpha; PPARGC1; PPARGC1A; PPARGC-1-alpha
• Gene Symbols: Ppargc1a
• Host Species: Rabbit
• Immunogen: Recombinant protein made to an internal portion of the human PGC-1 alpha protein (within residues 400-550).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100753651, 100861288, 10891, 19017, 397013, 443270, 479127, 83516
• Target Species: Human, Mouse, Rat, Canine, Sheep, Hamster, Pig, Rodent, Goat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG