Invitrogen™ NPR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA131202

Catalog No. PIPA131202

Description

Recommended positive controls: Brain, kidney and spleen.

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms. The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A and type B. Also see NPR3, which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides and BNP, respectively).

Specifications

• Antigen: NPR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NPR1
• Gene Alias: AI893888; ANPa; ANP-A; ANPRA; ANPR-A; atrial natriuretic peptide A-type receptor; atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor A; atrial natriuretic peptide receptor type A; atrionatriuretic peptide receptor A; Gca; GC-A; Guanylate cyclase A; guanylyl cyclase-A; GUC2A; GUCY2A; natriuretic peptide A type receptor; natriuretic peptide receptor 1; natriuretic peptide receptor A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); Nppa receptor; Npr1; Npra; NPR-A; Pndr; testicular tissue protein Li 20
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18160, 24603, 4881
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 0.85 mg/mL
• Formulation: Tris glycine with 0.5% BSA, 30% glycerol and 0.02% sodium azide; pH 7.4-7.9
• Gene Accession No.: P16066, P18293, P18910
• Gene Symbols: NPR1
• Immunogen: Synthetic peptide corresponding to C terminal amino acids 1042-1057 of Human NPRA.Sequence:VRTYWLLGERGCSTRG.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov