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Invitrogen™ PGPEP1 Polyclonal Antibody
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Catalog No. PIPA547827
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100 μg
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Catalog No. Quantity
PIPA547827 100 μg
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Catalog No. PIPA547827 Supplier Invitrogen™ Supplier No. PA547827
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Description

Sheep Polyclonal Antibody

Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

Pyroglutamyl-peptidase I (PGPEP1) is a gene located on chromosome 19q13.33, encoding an enzyme involved in the removal of pyroglutamyl residues from the N-terminus of peptides and proteins. This enzymatic activity is fundamental in protein processing and metabolism, ensuring proper protein maturation and degradation. PGPEP1 is expressed in multiple tissues, including the liver and kidney, and plays a role in the regulation of biological processes by modulating the activity and stability of pyroglutamyl-containing bioactive peptides. The enzyme's function is crucial for maintaining cellular homeostasis and can influence physiological pathways such as hormone regulation and immune responses. Dysregulation or mutations in PGPEP1 may impact peptide function and have potential implications for various diseases, although the specific clinical significance is still being researched. Insights into PGPEP1's function are contributing to the understanding of protease-related disorders and therapeutic strategies targeting peptide metabolism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PGPEP1
Applications Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene PGPEP1
Gene Accession No. Q9ESW8, Q9NXJ5
Gene Alias 2810003H13Rik; 5-oxoprolyl-peptidase; Gm19458; PAPI; PAP-I; Pcp; PGI; pGlu-peptidase I; PGP; PGPEP1; PGPI; PGP-I; putative pyroglutamyl-peptidase I; pyroglutamyl aminopeptidase I; Pyroglutamyl-peptidase 1; pyroglutamyl-peptidase I; Pyrrolidone-carboxylate peptidase
Gene Symbols PGPEP1
Host Species Sheep
Immunogen E. coli-derived recombinant human PGPEP-1 Met1-His209.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54858, 66522
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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