Invitrogen™ PGPEP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA557245

Catalog No. PIPA557245

Description

Immunogen sequence: PESIDSIIDM DAVCKRVTTL GLDVSVTISQ DAGRYLCDFT YYTSLYQSHG RSAFVHVPPL GKPYNADQLG RALR Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.

Pyroglutamyl-peptidase I (PGPEP1) is a gene located on chromosome 19q13.33, encoding an enzyme involved in the removal of pyroglutamyl residues from the N-terminus of peptides and proteins. This enzymatic activity is fundamental in protein processing and metabolism, ensuring proper protein maturation and degradation. PGPEP1 is expressed in multiple tissues, including the liver and kidney, and plays a role in the regulation of biological processes by modulating the activity and stability of pyroglutamyl-containing bioactive peptides. The enzyme's function is crucial for maintaining cellular homeostasis and can influence physiological pathways such as hormone regulation and immune responses. Dysregulation or mutations in PGPEP1 may impact peptide function and have potential implications for various diseases, although the specific clinical significance is still being researched. Insights into PGPEP1's function are contributing to the understanding of protease-related disorders and therapeutic strategies targeting peptide metabolism.

Specifications

• Antigen: PGPEP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PGPEP1
• Gene Alias: 2810003H13Rik; 5-oxoprolyl-peptidase; Gm19458; PAPI; PAP-I; Pcp; PGI; pGlu-peptidase I; PGP; PGPEP1; PGPI; PGP-I; putative pyroglutamyl-peptidase I; pyroglutamyl aminopeptidase I; Pyroglutamyl-peptidase 1; pyroglutamyl-peptidase I; Pyrrolidone-carboxylate peptidase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54858
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NXJ5
• Gene Symbols: PGPEP1
• Immunogen: Recombinant protein corresponding to Human PGPEP1. Recombinant protein control fragment (Product #RP-95838).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov