Invitrogen™ PGPEP1 Polyclonal Antibody

Catalog No.	Quantity
PIPA5114267	100 μL

Catalog No. PIPA5114267 Supplier Invitrogen™ Supplier No. PA5114267

Description

Rabbit Polyclonal Antibody

Immunogen sequence: KHSPQLVVHV GVSGMATTVT LEKCGHNKGY KGLDNCRFCP GSQCCVEDGP For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 83%.

Pyroglutamyl-peptidase I (PGPEP1) is a gene located on chromosome 19q13.33, encoding an enzyme involved in the removal of pyroglutamyl residues from the N-terminus of peptides and proteins. This enzymatic activity is fundamental in protein processing and metabolism, ensuring proper protein maturation and degradation. PGPEP1 is expressed in multiple tissues, including the liver and kidney, and plays a role in the regulation of biological processes by modulating the activity and stability of pyroglutamyl-containing bioactive peptides. The enzyme's function is crucial for maintaining cellular homeostasis and can influence physiological pathways such as hormone regulation and immune responses. Dysregulation or mutations in PGPEP1 may impact peptide function and have potential implications for various diseases, although the specific clinical significance is still being researched. Insights into PGPEP1's function are contributing to the understanding of protease-related disorders and therapeutic strategies targeting peptide metabolism.

Specifications

• Antigen: PGPEP1
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene: PGPEP1
• Gene Accession No.: Q9NXJ5
• Gene Alias: 2810003H13Rik; 5-oxoprolyl-peptidase; Gm19458; PAPI; PAP-I; Pcp; PGI; pGlu-peptidase I; PGP; PGPEP1; PGPI; PGP-I; putative pyroglutamyl-peptidase I; pyroglutamyl aminopeptidase I; Pyroglutamyl-peptidase 1; pyroglutamyl-peptidase I; Pyrrolidone-carboxylate peptidase
• Gene Symbols: PGPEP1
• Host Species: Rabbit
• Immunogen: Synthetic peptide directed towards the N-terminal region of Human PGPEP1 (aa 64-113).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 54858
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG