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Invitrogen™ PGRP-1a Monoclonal Antibody (187C434)
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Catalog No. 01676472
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200 μL
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Catalog No. Quantity
01-676-472 200 μL
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Catalog No. 01-676-472 Supplier Invitrogen™ Supplier No. MA141125
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Description

Mouse Monoclonal Antibody

Suggested positive control: human brain tissue, human brain protein.

Primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1, 2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-I beta) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4). PGRP-1a mRNA is highly expressed in esophagus, tonsils and thymus and to lesser extent in the stomach, rectum, and brain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PGRP-1a
Applications Flow Cytometry, Western Blot
Classification Monoclonal
Clone 187C434
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.05% sodium azide
Gene PGLYRP3
Gene Accession No. Q96LB9
Gene Alias Gm420; MGC149197; Peptidoglycan recognition protein 3; peptidoglycan recognition protein I alpha; peptidoglycan recognition protein I-alpha; Peptidoglycan recognition protein intermediate alpha; PGLYRP3; PGLYRPIalpha; PGRPIA; PGRP-Ialpha; PGRP-I-alpha
Gene Symbols PGLYRP3
Host Species Mouse
Immunogen KLH-conjugated synthetic peptide corresponding to amino acids 178-193 of human PGRP-1a.
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114771
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgM
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