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Tocris Bioscience™ PH 797804
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Catalog No. 586610
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58-661-0 10 mg
58-665-0 50 mg
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Catalog No. 58-661-0 Supplier Tocris Bioscience™ Supplier No. 5866/10
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Description

Potent and selective p38α/β inhibitor

PH 797804 is a potent and selective p38α/β inhibitor (IC50 values are 26 and 102 nM, respectively). Exhibits >100-fold selectivity for p38α/β over 71 other kinases, enzymes and GPCRs, including p38γ, p38δ, JNK and ERK2. Inhibits LPS-induced TNFα production in U937 monocytes in vitro. Suppresses acute and chronic inflammatory responses in rat models of arthritis. Orally active.

PH 797804 is the (-)-atropisomer, which is 100-fold more potent than its (+)-atropisomer.

Specifications

Chemical Name or Material (-)-3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethylbenzamide
CAS 1358027-80-1
Quantity 10 mg
Target p38 Inhibitors
Molecular Formula C22H19BrF2N2O3
Formula Weight 477.3
Purity >98%
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